In Bios: Genesis (Second Edition) by Phil Eklund You will try to capture the entire conception and evolution of life over the first 4 billionyear history of our planet. And not just throw some cards and tokens around with molecular art, butactually express the dynamics and relationships of life struggling to find purchase in a hostile world. This is as close as you will get to being a biological compound evolving over 4 billion years of geologic time.
You start as an ingredient in the primordial soup and try to create life. Included are solitaire, competitive, and cooperative play options.
Each turn an event card is flipped, and catastrophes are resolved from left to right, determining the climate, stripping cubes from organisms and refugia placards, and creating new landforms that can harbor life. Any organisms which lose all of their cubes go extinct. The Event cards also dictate turn order and which refugia and mutation card piles are active at that turn.
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